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Image Search Results
Journal: Frontiers in Neurology
Article Title: Novel Surrogate Markers of CNS Inflammation in CSF in the Diagnosis of Autoimmune Encephalitis
doi: 10.3389/fneur.2019.01390
Figure Lengend Snippet: CSF cytokines. (A) Heat map cluster distinguishes viral from AbPAE and AbNAE encephalitis. Each column represents a participant. The X-axis identifies the cohort each participant belongs to, while the right-handed Y axis describes the corresponding cytokine. Increasing expression is depicted as increasing shades of red. Th1 and proinflammatory cytokines appear to be associated with viral infections, with the addition of IL7a, IL1b, and IL4 associated with enterovirus infections in this group. (B) Cytokines where a significant difference was found in univariate analysis of the autoimmune encephalitis group compared with a combined pool of NI, viral, and other autoimmune disease controls. Cytokines where the statistical significance was also seen in a univariate analysis are indicated with asterisks (* < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001). Statistical significance seen in multivariate analysis are indicated with hatches (# < 0.05, ## < 0.01, ### < 0.001, #### < 0.0001). Lines indicate medians. details the p-values of individual group comparisons. AbPAE, patients clinically high risk for autoimmune encephalitis who had identified associated antibodies; AbNAE, patients clinically high risk for autoimmune encephalitis without identified associated antibodies; NI, samples from patients either undergoing perioperative anesthesia or diagnosed with non-inflammatory neurological diseases; OAND, patients with other inflammatory neurological disease; EBV, Epstein Barr virus; VZV, varicella zoster virus; HSV, herpes simplex virus; ENT, enterovirus.
Article Snippet: Heat map analysis of
Techniques: Expressing, Virus